MovDisordV3, Main, Exploration, bibRecord, 005711

Amyloid β‐peptide and the dementia of Parkinson's diease

Identifieur interne : 005711 ( Main/Exploration ); précédent : 005710; suivant : 005712

Amyloid β‐peptide and the dementia of Parkinson's diease

Auteurs : Jendroska [Allemagne] ; Andrew Lees (neurologue) [Royaume-Uni] ; Werner Poewe [Autriche] ; Susan E. Daniel [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 1996-11.

RBID : ISTEX:E82192D3EE94337E797CB52CDC2F7EC025A6806D

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (pathology), Alzheimer's disease, Amyloid beta-Peptides (analysis), Brain (pathology), Cerebral Cortex (pathology), Dementia, Dementia (pathology), Diagnosis, Differential, Female, Humans, Image Processing, Computer-Assisted, Lewy Bodies (pathology), Lewy body, Male, Middle Aged, Neurofibrillary Tangles (pathology), Neuro‐fibrillary tangle, Parkinson Disease (pathology), Parkinson's disease, Reference Values, β‐Amyloid.
MESH :
- chemical , analysis : Amyloid beta-Peptides.
- pathology : Alzheimer Disease, Brain, Cerebral Cortex, Dementia, Lewy Bodies, Neurofibrillary Tangles, Parkinson Disease.
- Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Reference Values.

Abstract

It is not known whether an increased incidence of dementia in patients with Parkinson's disease (PD) is due to a higher incidence of Alzheimer's disease (AD) or to “early” Alzheimer‐type pathology. To determine whether amyloid β‐peptide (Aβ) of AD occurs more frequently in brains of patients with PD, we examined 50 cases and 79 controls by using histoblots for Aβ. Twentythree cases with PD had dementia, including all nine with Aβ distributed throughout the entire cerebral cortex; three of these cases had AD. In contrast, five of 17 controls with comparable Aβ accumulation were not demented. Neither AD nor Aβ deposition was increased in PD; furthermore, there was no statistical correlation between the amount of Aβ and the number of Lewy bodies in cerebral cortex. In 14 patients with PD in whom dementia was unrelated to Aβ, there was cerebral vascular disease (four), numerous cortical Lewy bodies (three), or hydrocephalus (two); in five further cases, dementia was not well explained by histopathologic changes. Our data found no increase of either AD or “early” Alzheimer‐type pathology in cases of PD; however, a synergistic effect between the two pathologies was suggested as contributing to dementia.

Url:

https://api.istex.fr/document/E82192D3EE94337E797CB52CDC2F7EC025A6806D/fulltext/pdf

DOI: 10.1002/mds.870110609

Affiliations:

Le document en format XML

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<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
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<term>Brain (pathology)</term>
<term>Cerebral Cortex (pathology)</term>
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<term>Dementia (pathology)</term>
<term>Diagnosis, Differential</term>
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<term>Image Processing, Computer-Assisted</term>
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<term>Middle Aged</term>
<term>Neurofibrillary Tangles (pathology)</term>
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<front><div type="abstract" xml:lang="en">It is not known whether an increased incidence of dementia in patients with Parkinson's disease (PD) is due to a higher incidence of Alzheimer's disease (AD) or to “early” Alzheimer‐type pathology. To determine whether amyloid β‐peptide (Aβ) of AD occurs more frequently in brains of patients with PD, we examined 50 cases and 79 controls by using histoblots for Aβ. Twentythree cases with PD had dementia, including all nine with Aβ distributed throughout the entire cerebral cortex; three of these cases had AD. In contrast, five of 17 controls with comparable Aβ accumulation were not demented. Neither AD nor Aβ deposition was increased in PD; furthermore, there was no statistical correlation between the amount of Aβ and the number of Lewy bodies in cerebral cortex. In 14 patients with PD in whom dementia was unrelated to Aβ, there was cerebral vascular disease (four), numerous cortical Lewy bodies (three), or hydrocephalus (two); in five further cases, dementia was not well explained by histopathologic changes. Our data found no increase of either AD or “early” Alzheimer‐type pathology in cases of PD; however, a synergistic effect between the two pathologies was suggested as contributing to dementia.</div>
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Movement Disorders (revue)

Amyloid β‐peptide and the dementia of Parkinson's diease

Amyloid β‐peptide and the dementia of Parkinson's diease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.